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The further two-sample t -tests, also considering the FDR (Table S2 e S3), evidenced ten metabolites (3-hydroxybutyrate, isoleucine, alanine, valine, acetone, acetoacetate, leucine, lactate, phenylalanine, acetate) as significantly changed in the plasma, and three (acetoacetate, succinate and 3-hydroxybutyrate) in the pericardial fluid of IHD patients in comparison with controls, highlighted by the red dotted circle in VIP scores models in Fig